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The global market size for DNA synthesis is expected to reach USD 12.76 billion by 2030. The market is expected to register a CAGR of 19.63% from 2023 to 2030 due to the increasing focus on personalized genome sequencing that is driving patient care.
In addition, DNA synthesis has the ability to revolutionize biological research activities for widespread applications in disease surveillance, drug discovery, and pharmacogenomics.
Advances in enzyme engineering encourage the development of different approaches to enzymatic DNA synthesis. It involves the use of enzymes to concatenate the nucleic acids together in the required sequence and requires further optimization for its widespread applications.
Many market participants are striving to develop novel technologies for the efficient enzymatic production of nucleotides in the shortest possible throughput time. For example, Ribbon Biolabs set a goal in May 2021 to synthesize 10,000 base pair DNA sequences and reached a milestone of a 20,000 base pair DNA molecule by December 2021.
Gene synthesis has a wide range of applications in site-directed mutagenesis with a specific sequence of nucleotides together with the regulation of a desired phenotypic expression. It forms the primary basis of genetic engineering, which has greatly improved the scope and quality of antibodies through the development of antibody fragments with high specificity.
Oligonucleotide synthesis is the laboratory-based production of relatively short fragments of nucleic acids in a required definitive sequence. The technique is an extremely robust practice that allows quick and inexpensive access to the tailored oligonucleotides of the desired sequence. Companies have developed their oligonucleotide libraries to support their nucleotide synthesis processes. For example, in July 2022, Ribbon Biolabs announced that it had secured a US patent covering Ribbon Biolabs’ method for synthesizing a nucleotide molecule using a diverse library of oligonucleotides. The approach includes a ready-made library of oligonucleotides for efficient access.
Highlights of the DNA Synthesis market report
By type of service, oligonucleotide synthesis held the largest share in 2022 due to the increasing demand for synthetic nucleotide strands for their utility in research studies
By application, the research and development segment dominated the market in 2022 owing to the demand for synthetic nucleotides for a wide range of applications in bioengineering and mRNA-based vaccines
In terms of end use, the biopharmaceutical company segment is expected to grow rapidly over the forecast period as applications of synthetic nucleotides to utilize biomolecular therapies increase. The increasing demand for novel drug discovery is also having a positive impact on the growth of this segment
North America dominated the global market in 2022 due to emerging advances in life science research and the rapidly growing demand for novel biotherapeutics in the region
Asia Pacific is expected to grow significantly due to increasing demand for biological research and novel drug discovery. In addition, key market players are working to enter the Asia-Pacific market with their expertise in advanced nucleotide production
Rapid technological advances in the field of synthetic biology
Increasing investment in research and development (R&D) activities.
Potential biosecurity, biosecurity and ethical issues
Strict government regulations and guidelines
Main topics covered:
Chapter 1 Methodology and Scope
Chapter 2 summary
Chapter 3 Market Variables, Trends and Scope
Chapter 4 Services Type Business Analysis
4.1 Oligonucleotide Synthesis
4.2 Gene Synthesis
Chapter 5 Application Analysis
5.1 Research & Development
Chapter 6 End Use Analysis
6.1 Biopharmaceutical Companies
6.2 Academic and Research Institutes
Chapter 7 Regional Business Analysis
Chapter 8 Company Profiles
Thermo Fisher Scientific, Inc.
twist life sciences
LGC Biosearch technology
Integrated DNA Technologies, Inc.
Quintara Life Sciences
GenScript Biotech Corporation
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